LDOC1 connects histone H2B monoubiquitination to tumor cell plasticity in non-small cell lung cancer.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, partly because epigenetic dysregulation drives tumor progression and metastasis. We previously showed that leucine zipper downregulated in cancer 1 (LDOC1) modulates the metastatic potential of NSCLC cells. The structural features of LDOC1 suggest that it can interact with nuclear histones, and although it lacks a canonical nuclear localization signal, it predominantly localizes to the nucleus in NSCLC cells; its loss causes broad transcriptomic changes, supporting a role for LDOC1 as an epigenetic regulator acting through histone modifications.

Methods

The levels of histone proteins were assessed in NSCLC cell lines with either LDOC1 knockdown or ectopic expression. Transcript

SUBMITTER: Huang HN 

PROVIDER: S-EPMC12853606 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature