Pu-erh tea attenuates obesity by remodeling gut microbiota and activating energy expenditure.

ABSTRACT:

Introduction

Energy excess-induced obesity has emerged as a global public health concern, and Pu-erh tea has attracted extensive research interest due to its prominent anti-obesity potential. This study aimed to investigate the anti-obesity activity of Pu-erh tea extract (PTE) and its underlying molecular mechanisms.

Methods

High-fat diet (HFD)-fed mice were used as the experimental model and subjected to Pu-erh tea extract (PTE) intervention. Whole-body energy metabolism of the mice was monitored using metabolic cages; morphological analysis was performed to characterize the lipid droplet distribution in brown adipose tissue (BAT); transcriptomic and lipidomic techniques were integrated to systematically detect changes in the gene expression profile and lipid composition in

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12853662 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature