A threshold effect of Apolipoprotein A1 levels on systemic inflammatory response index in individuals with osteoporotic fractures: a cross-sectional study.

ABSTRACT:

Background

Chronic inflammation and lipid metabolism are closely associated with osteoporotic fractures. Previous studies have reported associations between Apolipoprotein A1 (ApoA1) and inflammatory markers in specific inflammatory diseases. Nevertheless, the association between ApoA1 and the Systemic Inflammatory Response Index (SIRI) has been scarcely investigated in populations with osteoporotic fractures. We therefore conducted this cross-sectional study to examine this association.

Methods

In this cross-sectional study, 2067 patients with osteoporotic fractures (OPF) needing surgical intervention at Kunshan Hospital affiliated with Jiangsu University from January 2017 to July 2022 were enrolled. The relationship between serum ApoA1 concentrations and SIRI was evaluated

SUBMITTER: Lin GJ 

PROVIDER: S-EPMC12853704 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature