Intravenous delivery of mesenchymal stromal cells reverses Muller cell endoplasmic reticulum stress in diabetic retinopathy.

ABSTRACT:

Background

Mesenchymal stromal cells (MSCs) have emerged as a promising disease-modifying therapy for the complications of diabetes mellitus (DM), including diabetic retinopathy (DR). However, the optimal treatment regimen remains unclear, and challenges persist regarding the timing, route of delivery and the mechanisms underlying the therapeutic effects. This study focused on human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs), to elucidate their retinal protective effects, and investigate the underlying mechanisms by which a single intravenous injection might ameliorate the pathological alterations of DR.

Methods

Two time points after the development of DM were chosen for the in vivo experiments to study the effects of the intervention after different times o

SUBMITTER: Yan W 

PROVIDER: S-EPMC12853727 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature