Causal relationship between diet and common female diseases: a comprehensive Mendelian randomization study.

ABSTRACT:

Objective

This study aimed to investigate the causal relationship between dietary habits and nine common diseases with high female prevalence using a two-sample Mendelian randomization (MR) approach.

Methods

Drawing upon pooled Genome-Wide Association Study (GWAS) data from European cohorts, this research interrogated genetic associations across 21 detailed dietary classifications and nine major diseases with high prevalence in women.

Results

Our study identified multiple associations between dietary factors and gynecological disease risks. In initial analyses, dried fruit was inversely associated with breast and cervical cancer, while beef increased breast cancer risk. Endometrial cancer risk was linked to coffee, alcohol, and non-oily fish. Ovarian cancer risk exhib

SUBMITTER: Fu M 

PROVIDER: S-EPMC12853745 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature