Self-assembled nanonetworks of highly stable gemini surfactant-like peptides: antibacterial mechanisms, self-assembly characteristics, and in vivo anti-infection potential.

ABSTRACT: The escalating prevalence of bacterial resistance underscores the critical demand for developing non-antibiotic therapeutic candidates. Antimicrobial peptides (AMPs) with potent efficacy and low toxicity have emerged as a promising alternative strategy; however, their suboptimal proteolytic stability and bioavailability remain major obstacles to clinical application. Designing self-assembled nanosystems that coordinate the rational arrangement of amino acids to enhance the protease degradation resistance of AMPs provides a breakthrough solution for overcoming their stability bottlenecks. Drawing inspiration from the structure and self-assembly properties of gemini surfactants, we have developed a series of structural templates for gemini surfactant-like peptides that self-assemble through

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12853757 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature