Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins.

ABSTRACT: Bacteroidales are abundant Gram-negative bacteria present in the gut microbiota of most animals, including humans, where they carry out vital functions for host health. To thrive in this competitive environment, Bacteroidales use sophisticated weapons to outmatch competitors. Among these, Bacteroidales secreted antimicrobial proteins (BSAPs) represent a novel class of bactericidal pore-forming toxins that are highly specific to their receptor, typically targeting only a single membrane protein or lipopolysaccharide. The molecular determinants conferring this high selectivity remain unknown. In this study, we therefore investigated the model protein BSAP-1 and determined which of its domains is involved in providing receptor specificity. We demonstrate that receptor recognition is entirely

SUBMITTER: Borgini S 

PROVIDER: S-EPMC12853789 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature