Neoadjuvant chemo-reirradiation followed by resection and intraoperative electron beam radiotherapy: outcomes of multimodality treatment for locally recurrent rectal cancer.

ABSTRACT:

Background

Chemo-reirradiation has emerged as a feasible neoadjuvant therapy to improve resectability in locally recurrent rectal cancer (LRRC). However, its combination with surgery and intraoperative electron radiotherapy (IOERT) raises concerns regarding cumulative toxicity. This retrospective study aimed to evaluate acute and late toxicity profiles, local control and survival outcomes, following this multimodal approach in our institution.

Methods

LRRC patients who underwent chemo-reirradiation and surgery with IOERT (median cumulative tumour dose of 113 Gy, α/β = 10 Gy) between September 2021 to December 2024 were retrospectively analysed. Acute and late treatment-related toxicities (CTCAE) were recorded in a prospectively maintained database. Secondary outcomes were ov

SUBMITTER: Vande Kerckhove FEC 

PROVIDER: S-EPMC12853834 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature