Do the redefined EUCAST susceptibility categories warrant adjustment of paediatric antibiotic dosages? Pragmatic physiologically based pharmacokinetic modelling of four commonly used agents.

ABSTRACT:

Background and objective

With the redefinition of the EUCAST 'I' susceptibility category, from 'intermediate' to 'susceptible, increased exposure', the focus is now to use higher doses to treat infections of this category. These higher dosages in adults provided by EUCAST are fixed, yet it is uncertain whether a similar increase should apply to paediatric doses. We aimed to compare antibiotic exposure in adults and children, using pragmatic physiologically based pharmacokinetic (PBPK) modelling and simulation to evaluate the need for dose increases in children for the 'I' susceptibility category micro-organisms.

Methods

For amoxicillin, ceftazidime, cefuroxime and ciprofloxacin, we used existing PBPK models and verified them with published adult and paediatric pharmacokineti

SUBMITTER: de Hoop-Sommen MA 

PROVIDER: S-EPMC12853878 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature