Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study.

ABSTRACT:

Background

Separation from venovenous extracorporeal membrane oxygenation (VV-ECMO) is a pivotal transition for patients with acute respiratory distress syndrome (ARDS). Impaired alveolar ventilation more so than oxygenation may be implicated in weaning failure. The ventilatory ratio (VR), a simple marker of patient ventilatory efficiency, correlates with physiological dead space and ARDS outcomes. We hypothesised that elevated VR measured during sweep gas off trials (SGOT) predicts unsafe liberation from VV-ECMO.

Methods

In this monocentric retrospective study, adult patients undergoing VV-ECMO for ARDS between July 2019 and August 2023 were recruited. Patients who died on ECMO or were palliatively separated were excluded. Physiological, ventilatory and ECMO data were extra

SUBMITTER: Worku E 

PROVIDER: S-EPMC12853893 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature