Enhancement of growth and zeaxanthin accumulation via gene expression and metabolic pathways modulation in Chromochloris zofingiensis mutant CZ-Z12.

ABSTRACT:

Background

Chromochloris zofingiensis is recognized as a promising resource for the production of carotenoids. However, current knowledge regarding its capacity for zeaxanthin accumulation remains limited, which restricts its potential for commercial application. The development of high-yielding strains and an understanding of the underlying metabolic and regulatory mechanisms are critical to advancing large-scale zeaxanthin production.

Results

In this study, a novel zeaxanthin-enriched mutant CZ-Z12 was obtained using ethyl methyl sulfonate (EMS). CZ-Z12 displayed a rapid growth rate when cultivated heterotrophically. On Day 6, zeaxanthin content and total fatty acid (TFA) content reached 0.229% and 28.6% of dry weight (DW), representing a 4.1 and 1.9-fold increase compared

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12853952 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature