Cerium-doped prussian blue nanozymes for bone regeneration and osteoprotection by Lhx2 in sutural distraction osteogenesis through multi-omics analysis.

ABSTRACT: Sutural distraction osteogenesis (SDO) involves the induction of new bone formation in the suture region through external distraction, widely employed for treating craniomaxillofacial deformities such as craniosynostosis and maxillary transverse hypoplasia. Nonetheless, there remains a deficiency in effective and minimally invasive therapeutic approaches to shorten the treatment duration and minimize the risk of relapse. Prussian blue (PB) nanozymes exhibit extensive biological applications due to their superior biocompatibility and enzyme-like activity. Incorporating cerium (Ce), which possesses REDOX and osteopromoting properties, into Prussian blue nanozymes not only preserves its excellent biosafety but also enhances stem cell recruitment and bidirectional regulation of osteogenesis pr

SUBMITTER: Zhao H 

PROVIDER: S-EPMC12853962 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature