Clusterzymes-driven therapy: ultrasmall Cu₄ nanoclusters achieve dual-pronged synergistic effects on antioxidant defense and ferroptosis Inhibition for inflammatory osteolysis.

ABSTRACT: Inflammatory osteolysis represents a critical complication following orthopedic interventions such as total joint replacement, primarily triggered by persistent inflammatory responses induced by prosthetic wear debris or bacterial components like lipopolysaccharides (LPS). Inflammatory osteolysis, a severe complication of orthopedic interventions like total joint replacement, is driven by prosthetic wear debris or lipopolysaccharides (LPS)-induced persistent inflammation and osteoclast activation. Current therapeutic strategies are limited by significant side effects and their inability to simultaneously halt the synergistic pathological processes of inflammation and osteoclast activation, highlighting an urgent need for novel therapeutic approaches. In this study, we synthesized ultrasmal

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12853966 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature