Biomimetic nanovesicles decorated with chemotactic and target membrane proteins for lupus nephritis treatment.

ABSTRACT: Cell membrane-coated drug delivery systems show advantages of immune escape and bio-mimicking targeting capacity; attention in this area is focusing on further enhancing their targetability for specific cells to improve delivery efficacy and therapeutic effectiveness. Here, we report a novel biomimetic nano-delivery system featured with dual‑targeting and antioxidant capacity to combat refractory lupus nephritis (LN) and promote renal injury repair. The nanocarriers of the system were prepared by cloaking glucocorticoid methylprednisolone (MP)-loaded mesoporous dopamine nanoparticles (mPDA) with chemokine receptor 4 (CXCR4)-expressing mesenchymal stem cell membranes, which inherit chemotactic and immune escape properties. In addition, by inserting the bovine serum albumin (BSA) link onto t

SUBMITTER: Gan J 

PROVIDER: S-EPMC12853968 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature