Pregnancy Outcomes in Women With Systemic Sclerosis Before and/or After Diagnosis and by Parity: A Swedish Population-Based Cohort Study.

ABSTRACT:

Objective

To assess risks of adverse pregnancy outcomes (APOs) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity.

Methods

From the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population (1998-2021). We classified pregnancies according to the timing of SSc diagnosis at birth: post-SSc (after SSc diagnosis [n = 94]) and pre-SSc (zero to three years [n = 39] or more than three years [n = 839] before diagnosis of SSc). We used regression models estimating relative risks (RRs) and odds ratios of APOs with 95% confidence intervals (CIs) in post-SSc and pre-SSc pregnancies, respectively.

Results

For post-SSc pre

SUBMITTER: Che WI 

PROVIDER: S-EPMC12853999 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature