Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody-Positive Individuals.

ABSTRACT:

Objective

The transition from asymptomatic antinuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of proinflammatory factors such as tumor necrosis factor α (TNFα). Here we investigate whether the relative absence of inflammation in asymptomatic ANA⁺ individuals (ANA⁺NS) results from a lack of circulating immune complexes (ICs) or from changes in the characteristics of the IgG autoantibodies produced.

Methods

Flow cytometry was used to characterize circulating microparticles (MPs) in 18 healthy controls (ANA^-HC), 31 ANA⁺NS, and 51 symptomatic ANA⁺ patients. Differences in the ability of the total MPs, purified IgG-coated MPs, or aggregated IgG to elic

SUBMITTER: Munoz-Grajales C 

PROVIDER: S-EPMC12854008 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature