Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8⁺ T Cell Clones.

ABSTRACT:

Objective

Psoriatic arthritis (PsA) is an HLA class I-associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8⁺ T cell phenotype and clonality.

Methods

Using single-cell RNA sequencing (n = 6 skin samples with n = 5 paired synovial tissue samples and/or n = 5 paired synovial fluid samples) and spatial transcriptomics (n = 1 paired skin and synovial biopsy sample, n = 4 unpaired biopsy samples), we compared the transcriptional signature, T cell receptor repertoire, and cell neighborhoods of T cells from skin and synovial tissue and/or fluid samples from patients with PsA.

Results

We identified an enrichment of type 17 CD8⁺ tissu

SUBMITTER: Durham LE 

PROVIDER: S-EPMC12854012 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature