Associations of self- and informant-reported functional impairment with cognitive performance and incident dementia.

ABSTRACT:

Introduction

Functional impairment is central to dementia diagnosis, typically assessed through basic and instrumental activities of daily living (ADLs/IADLs) reported by participants or informants. However, it remains unclear which items and reporting sources best capture cognition-related functional impairment.

Methods

We analysed data from 1,050 adults aged ≥65 years in the English Longitudinal Study of Ageing Harmonised Cognitive Assessment Protocol. Self- and informant-reported ADL and IADL impairments were examined at overall and item levels. Associations with general and domain-specific cognition were estimated using linear regression, and with incident dementia over 6.7 years using Cox models, both adjusted for socioeconomic, lifestyle, and health factors.

Results

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12854031 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature