Associations of threat- and deprivation-related adverse childhood experiences with risk of cardiovascular disease in later life.

ABSTRACT: Exposure to adverse childhood experiences (ACEs) has consistent associations with increased long-term risk of cardiovascular disease (CVD). However, links of distinct ACE subtypes and particular ACEs with later-life CVD are insufficiently understood. This longitudinal cohort study initially recruited 20,452 participants from the China Health and Retirement Longitudinal Study and Life History Survey. Follow-up data were obtained from five waves conducted between 2011 and 2020. ACEs were measured with ten items adapted from the Life Stressor Checklist-Revised, a measure that includes five threat-related ACEs and five deprivation-related ACEs. The outcome measure was CVD (including heart disease and stroke) during the follow-up period. Multivariate Cox proportional hazards regression models a

SUBMITTER: Chen ZM 

PROVIDER: S-EPMC12854044 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature