Effects of branched-chain amino acids on iron deficiency-induced muscle atrophy.

ABSTRACT: Iron deficiency (ID) is a potential contributor to skeletal muscle atrophy through disruption of the balance between protein synthesis and degradation. This muscle loss is associated with sarcopenia and locomotive syndrome, conditions that impair mobility and reduce healthy life expectancy. While branched-chain amino acids (BCAA) are known to attenuate dexamethasone-induced muscle atrophy, its effectiveness against ID-induced atrophy has not been fully elucidated. This study aims to investigate the effects of BCAA on ID-induced muscle atrophy in C2C12 myotubes treated with the iron chelator deferoxamine (DFO). Results showed that DFO significantly reduced myotube diameter and upregulated atrogenes such as Atrogin-1 and MuRF-1, accompanied by increased p-AMPK and p-eEF2, and decreased p-Akt

SUBMITTER: Kawanaka M 

PROVIDER: S-EPMC12854053 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature