Association of Blood Urea Nitrogen With Incident Heart Failure in the Community　- The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Background

The association between blood urea nitrogen (BUN) levels and incident heart failure (HF) in the general population is still unclear.

Methods and results

We assessed the association of BUN level with incident HF in 14,167 ARIC participants without a history of HF at baseline (1987-1989) (mean age 54.1 years, 54.4% female, 25.2% Black). BUN levels (mg/dL) were divided into quartiles, with the highest quartile further divided into tertiles (Q1 ≤13, Q2 13-15, Q3 15-17, Q4a 17-19, Q4b 19-21, Q4c >21). HF events were identified through to December 31, 2019, using diagnostic codes on discharge records or death certificates. Hazard ratios (HRs) were estimated using multivariable Cox models. During a median follow-up of 26.2 years, 3,482 participants developed HF (incidenc

SUBMITTER: Liu H 

PROVIDER: S-EPMC12854080 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature