Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.

ABSTRACT:

Objective

To determine whether extending caffeine therapy through 43 weeks' postmenstrual age (PMA) decreases intermittent hypoxia (IH) in convalescing preterm infants. Secondary objectives were to assess caffeine effects on changes in inflammation-related plasma biomarkers and brain MRI.

Design

Multicentre masked randomised trial.

Setting

16 US hospitals.

Patients

Infants at <30 weeks + 6 days gestational age on caffeine between 32 weeks and 36+5 days PMA in room air with routine caffeine discontinuation prior to 36 weeks +6 days.

Intervention

Randomisation to caffeine or placebo and treated through 42 completed weeks. Pulse oximetry was recorded from enrolment through 1 week after stopping study drug. Blood for 12 inflammation-related biomarkers obtain

SUBMITTER: Eichenwald E 

PROVIDER: S-EPMC12854145 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature