Multi-Omics Evidence Based on Spatial Transcriptomics Data Reveals the Therapeutic Value of Copper Death Genes in Glioblastoma.

ABSTRACT:

Background

Cuprotosis is an emerging form of copper-dependent programmed cell death, while low-grade gliomas (LGGs) represent a common subtype of primary brain tumors.

Methods

Datasets from The Cancer Genome Atlas and TargetScan were utilized to identify cuprotosis-related microRNAs (CRMs). Univariate Cox and Lasso regression analyses identified CRMs linked to prognostic outcomes. Prognostic profiles for patients with LGG were constructed using multivariate Cox regression and validated for risk stratification in the CGGA external validation cohort. The study examined clinical features, mutational status, immune cell infiltration, signaling pathways, and immune checkpoint expression across different risk groups. Functional experiments assessed the biological significance of k

SUBMITTER: Xue Z 

PROVIDER: S-EPMC12854168 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature