Live-attenuated African swine fever vaccine HLJ/18-7GD is safe in pregnant sows with no impact on reproductive performance or offspring health at a field farm.

ABSTRACT: African swine fever (ASF) continues to pose a threat to the global pig industry. Previously, we generated a Georgia-07-like genotype II African swine fever virus (ASFV)-based gene-deleted live vaccine (HLJ/18-7GD) and demonstrated that it is safe for pigs and pregnant sows and effective against the parent virus in the laboratory. Here, we report a systematic field safety assessment of HLJ/18-7GD in 201 sows and their offspring across two parities in a real-world farm scenario performed over more than 11 months. Pregnant sows inoculated with HLJ/18-7GD presented no disease signs or adverse reactions and no changes in gestational status or reproductive performance. Inoculation of sows with HLJ/18-7GD did not affect the health, growth or fattening of first- or second- parity offspring. HLJ/18

SUBMITTER: Liu J 

PROVIDER: S-EPMC12854226 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature