Effect of 3-Day Linaclotide Administration to Reduce the Polyethylene Glycol Volume for Colonoscopy Bowel Preparation: A Multicenter, Noninferiority, Randomized Controlled Trial.

ABSTRACT:

Introduction

Several studies have investigated the role of linaclotide in bowel preparation; however, dosage and timing still warrant further exploration.

Methods

This noninferiority randomized controlled study was performed in 16 medical centers. The eligible subjects were randomly assigned to 3 groups: the Lct + 3 L polyethylene glycol (PEG) group (group A), the 3 L PEG group (group B), or the Lct + 2 L PEG group (group C). The primary outcome was the adequate bowel preparation rate based on the Boston Bowel Preparation Scale. Safety was assessed based on the incidence of adverse reactions.

Results

A total of 1,607 eligible subjects were enrolled, and 1,545 colonoscopy videos were uploaded. In the intention-to-treat analysis, the results of the noninferiority test i

SUBMITTER: Pan P 

PROVIDER: S-EPMC12854379 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature