An Autologous, Vascularized and Immunocompetent Tissue Engineered Skin to Highlight Inter-Individual Variability to Better Understand the Human Wound Healing.

ABSTRACT: In vitro tissue-engineered skin models are valuable tools for dermatological research. Yet, they often fail to reproduce the complex interactions among vascular, immune, and cutaneous cells during the wound healing process. In addition, inter-individual variability response remains poorly understood, limiting our knowledge of the genetic and environmental factors that influence wound healing. This study presents a 3D autologous, vascularised, and immunocompetent Tissue Engineered Skin model (aviTES), generated using cells from the same donor to study the wound healing process. The aviTES models were injured using a 2 mm punch biopsy, and wound closure was macroscopically monitored for 7 days in the absence of any stimuli. The re-epithelialisation rate was highly reproducible within the sam

SUBMITTER: Attiogbe E 

PROVIDER: S-EPMC12854395 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature