Association analysis of Mycoplasma pneumoniae 23S rRNA gene mutation with refractory Mycoplasma pneumoniae pneumonia in children.

ABSTRACT:

Objective

This study investigates the current status of macrolide resistance in Mycoplasma pneumoniae (MP) and analyzes the relationship between mutations at the 23S rRNA A2063G and/or A2064G loci and refractory Mycoplasma pneumoniae pneumonia (RMPP).

Methods

A retrospective analysis was conducted on 205 hospitalized children diagnosed with MPP at the Third Ward of the department of paediatrics, Jingzhou Central Hospital, from October 2023 to October 2024. Diagnosis was confirmed by pharyngeal MP nucleic acid testing and MP antibody titers (MP-Ab ≥ 1:160). All patients were screened for macrolide-resistant gene mutations (A2063G/A2064G). Patients were categorized based on the presence of macrolide-resistant gene mutations and RMPP diagnosis. Clinical features, laboratory res

SUBMITTER: Li W 

PROVIDER: S-EPMC12854454 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature