Investigation of the drug release modifying property of Pentadesma butyracea gum in diclofenac sodium matrix tablets.

ABSTRACT:

Background

Natural gums have long served as essential excipients in pharmaceutical formulations, traditionally functioning as binders, disintegrants, suspending agents, and emulsifiers. Their role has expanded to include drug delivery carriers in advanced systems such as matrix formulations, gene therapy, and nanomedicine. Increasing attention has been given to natural gums over synthetic alternatives due to their non-toxicity, biodegradability, affordability, and availability. This study investigated the potential of Pentadesma butyracea gum as a matrix-forming agent for the extended release of diclofenac sodium.

Methods

The crude gum was harvested from the stem bark of Pentadesma butyracea and purified using ethanol precipitation. Fourier-transform infrared spectroscopy (F

SUBMITTER: Archer MA 

PROVIDER: S-EPMC12854478 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature