MUC5B rs35705950 and its association with survival in Brazilian patients with idiopathic pulmonary fibrosis: A longitudinal cohort study.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with heterogeneous clinical outcomes. The MUC5B promoter polymorphism (rs35705950) is the most consistent genetic factor associated with IPF susceptibility, but data from Latin American populations remain limited.

Methods

We conducted a longitudinal cohort study including 50 patients with IPF and 45 healthy controls, recruited between August 1, 2018, and April 30, 2025, at a tertiary referral center in Brazil. Genotyping of rs35705950 was performed by real-time PCR. Demographic, clinical, and functional data were collected at baseline. Survival was analyzed using Kaplan-Meier curves and Cox regression models, with follow-up defined from symptom onset to death or censoring.

Results

SUBMITTER: Rufino R 

PROVIDER: S-EPMC12854480 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature