Surface HEI-OC1-Engineered Magnetic Nanoparticles with Antioxidant Coatings Mitigate Ototoxic Stress in HEI-OC1 Auditory Cells.

ABSTRACT: Hearing loss represents a major global health challenge. Particularly, ototoxicity induced by cisplatin and aminoglycosides remains a significant clinical problem. In this study, we synthesized and characterized magnetite nanoparticles (Fe₃O₄) functionalized with protocatechuic acid (Fe₃O₄@3,4-DHAB) and with protocatechuic acid plus sodium citrate (Fe₃O₄@3,4-DHAB@NaCitrate) and evaluated their effects on auditory House Ear Institute-Organ of Corti 1-(HEI-OC1) cells exposed to cisplatin and gentamicin. The nanoparticles exhibited good biocompatibility, maintaining a cell viability above 85% even at high concentrations. Functionalized formulations, particularly Fe₃O₄@3,4-DHAB, mitigated drug-induced loss

SUBMITTER: Cumpata AJ 

PROVIDER: S-EPMC12854489 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature