Controlled Cisplatin Delivery Using pH-Sensitive PAA-Grafted Mesoporous Silica Nanoparticles.

ABSTRACT: More than 70% of patients with ovarian cancer are diagnosed with metastasis, in which tumors spread to the peritoneal cavity. The current standards of care are intravenous (IV) or intraperitoneal (IP) injection of small-molecule anticancer drugs, such as cis-diamminedichloro platinum-(II) (cisplatin). Although IP injection enables delivery of higher drug concentrations to the tumor sites, the small molecules have low retention times. To overcome these challenges, we present two alternative nanoparticle-based formulations, namely, cisplatin-loaded dendritic mesoporous silica nanoparticles (Pt-MSNs) and poly-(acrylic acid) (PAA)-modified dendritic MSNs (Pt-PAA-MSNs). For both formulations, we obtained stable particles with uniform shapes/sizes that did not aggregate 15 days after i

SUBMITTER: Kashfi Sadabad R 

PROVIDER: S-EPMC12854506 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature