Noninvasive Nicotine Quantitation and Flavor Differentiation of <i>on!</i> Nicotine Pouches Using Raman Spectroscopy: A Direct, Reliable, and Preparation-Free Approach.

ABSTRACT: Nicotine pouches are a growing category in the smoke-free market, serving as an alternative to traditional tobacco products due to their noncombustible nature. Liquid and gas chromatography techniques coupled to various detectors were proven to be effective for determining nicotine content in tobacco products, including nicotine pouches. However, they require multiple steps and labor-intensive procedures for analysis. In this study, we developed a novel Raman spectroscopic method for accurately determining nicotine content in nicotine pouch products using a wide-area illumination scheme providing a 6 mm laser illumination diameter and a long focal length. Using chemometric tools, we analyzed 15 nicotine pouch products from a single commercially available brand (on! nicotine pouches)

SUBMITTER: Kim Y 

PROVIDER: S-EPMC12854618 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature