Respiratory Syncytial Virus F Protein Adjuvanted with a Carbomer-Based Adjuvant Induces Protective Humoral Response in Mice.

ABSTRACT: Carbomer-lecithin-based adjuvant Adjuplex has been shown to induce a balanced T cell response and high antibody titers with some of the viral pathogens. Here, we compared the humoral immune response in mice immunized intranasally with respiratory syncytial virus fusion (RSV-F) or glycoprotein (RSV-G) or both using Adjuplex and/or a TLR9 agonist, CpG oligodeoxynucleotide (ODN). Both the adjuvants elicited robust antibody response in mice; however, Adjuplex generated higher levels of neutralizing antibodies as compared to CpG ODN when used with RSV-F protein. Neutralizing antibody titers were associated with reduced RSV load in the lungs of immunized BALB/c mice upon intranasal challenge with the RSV A2 strain. RSV-G alone was insufficient to elicit a strong antibody response with either of

SUBMITTER: Singh S 

PROVIDER: S-EPMC12854629 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature