Anlotinib plus Chemotherapy for the Treatment of Refractory Primary Cardiac Intimal Sarcoma: A Case Report.

ABSTRACT:

Introduction

Primary cardiac intimal sarcoma (CIS) is a rare and highly malignant soft tissue tumor associated with an extremely poor prognosis. To date, there are no established treatment guidelines for CIS in clinical practice.

Case presentation

A 44-year-old man was diagnosed with left atrial intimal sarcoma. Forty-two days after radical surgical resection, he developed local recurrence accompanied by brain and gluteus medius metastases. The patient first received emergency radiotherapy for intracranial metastases, followed by six cycles of systemic chemotherapy with ifosfamide and epirubicin, combined with targeted therapy using anlotinib. Ultimately, he achieved an overall survival (OS) of 17 months.

Conclusion

To our knowledge, this is the first report describin

SUBMITTER: Guan W 

PROVIDER: S-EPMC12854688 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature