Enantioselective Michael Spirocyclization of Palladium Enolates.

ABSTRACT: We report an enantioselective and diastereoselective Michael spirocyclization reaction of tetrasubstituted palladium enolates. This allows for the formation of adjacent all-carbon quaternary and tertiary stereocenters in good yield, dr, and ee. Various subsequent cyclization reactions enable access to a diverse range of tricyclic scaffolds. The mechanism of this transformation and the origins of stereoselectivity are investigated via quantum mechanics calculations.

SUBMITTER: Strong CS 

PROVIDER: S-EPMC12854706 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature