Quantitative Assessment of Particulate Matter Biodistribution Using ¹⁴C-Nanotracing and Accelerator Mass Spectrometry.

ABSTRACT: Particulate matter (PM) poses a major health risk, yet quantifying the biodistribution of inhaled PM at an environmentally relevant concentration remains analytically challenging. Here, we developed a ¹⁴C-nanotracing platform integrated with accelerator mass spectrometry (AMS) to achieve subpicogram sensitivity for organ-level quantification of inhaled PM. ¹⁴C-labeled black carbon PM was generated via pyrolysis of ¹⁴C-n-hexane and introduced into a controlled inhalation chamber. ICR mice (n = 7) were exposed to short-intense (1 h, high concentration) and long-mild (3 h day^-1 for 7 days, low concentration) protocols to represent acute and subchronic exposure conditions. Quantitative AMS analysis revealed systemic translocation of car

SUBMITTER: Song S 

PROVIDER: S-EPMC12854748 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature