A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris.

ABSTRACT: Artemisia capillaris, a traditional Chinese medicinal plant, has displayed favourable effects in the treatment of jaundice, inflammation of the liver and cholecystitis for thousands of years. However, the biosynthesis of scoparone, the major active component in A. capillaris, remains unclear. Here, a full-length transcriptomic and integrated metabolomic dataset of A. capillaris was generated for the first time. A nearly complete map of the biosynthesis pathway of scoparone was subsequently proposed. Notably, a novel O-methyltransferase, AcOMT1, which catalyses the methylation of scopoletin and isoscopoletin as the final step in the biosynthesis of scoparone, was annotated and characterised using a weighted gene correlation network, phylogenetic analysis, subcellular localisation analysis a

SUBMITTER: Guo F 

PROVIDER: S-EPMC12854908 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature