Blood-mimicking dye phantoms for evaluating photoacoustic oximetry accuracy.

ABSTRACT: Many proposed clinical applications of photoacoustic imaging (PAI) rely on relative or absolute measurements of blood oxygen saturation (sO2), and evaluation of oximetry measurement accuracy is crucial for assessing device performance. Available bench test methods use phantoms connected to blood flow circuits with tunable oxygenation, but these methods are complex, costly, and pose biohazard safety risks. To address these issues, we have developed stable and tunable blood-mimicking solutions using binary mixtures of commercially available near-infrared organic dyes (NIR746A and IRA980) to enable non-biological phantom-based PAI oximetry test methods. We used spectrophotometry and a custom PA spectroscopy system to characterize dye extinction and PA response at 750 nm and 850 nm, then formu

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12854982 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature