Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer.

ABSTRACT: Cachexia is a wasting disorder associated with high morbidity and mortality in patients with cancer. Tumour-host interaction and maladaptive metabolic reprogramming are substantial, yet poorly understood, contributors to cachexia. Here we present a comprehensive overview of the spatio-temporal metabolic reprogramming during cachexia, using integrated metabolomics, RNA sequencing and ¹³C-glucose tracing data from multiple tissues and tumours of C26 tumour-bearing male mice at different disease stages. We identified one-carbon metabolism as a tissue-overarching pathway characteristic for metabolic wasting in mice and patients and linked to inflammation, glucose hypermetabolism and atrophy in muscle. The same metabolic rewiring also occurred in five additional mouse models, namely

SUBMITTER: Morigny P 

PROVIDER: S-EPMC12855018 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature