Adherence to the Healthy Low-Carbohydrate Diet and incident depression and anxiety.

ABSTRACT:

Background

This study investigated the prospective associations between adherence to a Healthy Low-Carbohydrate Diet (HLCD) and incident depression, anxiety, and their comorbidity, and explored the mediating role of inflammation.

Methods

This cohort study analyzed 173,207 participants from the UK Biobank. The HLCD score was calculated based on the intake of total carbohydrate, vegetable protein, and unsaturated fat. Cox proportional hazards models and restricted cubic splines were used to examine linear and non-linear associations, respectively. Mediation analyses assessed the contribution of inflammatory markers.

Results

Compared with the lowest HLCD score group (scores 0-6), the lowest risks were observed in the third group (scores 13-18) for depression (hazard rati

SUBMITTER: Qin T 

PROVIDER: S-EPMC12855048 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature