Modified Sanjia Powder ameliorates cognitive impairment and exerts neuroprotective effects in 5 × FAD mice: insights from quantitative proteomics.

ABSTRACT:

Background

Modified Sanjia Powder (MSP) is a traditional Chinese herbal formulation with potential use as a dietary supplement, which has shown neuroprotective properties against Alzheimer's disease (AD). However, its mechanisms of action, particularly those related to metabolic pathways, remain poorly understood. Given the emerging role of lipid metabolism and associated oxidative stress in AD pathogenesis, this study aimed to investigate the therapeutic effects of MSP on cognitive impairment and explore its molecular mechanisms, with emphasis on nutritionally relevant pathways, in the 5 × FAD mouse model of AD using quantitative proteomics.

Methods

Cognitive, pathological, and molecular functions were evaluated following MSP treatment. Cognitive performance was assessed us

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12855056 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature