Spontaneous spike-and-wave discharges during sleep in mice: circadian distribution and impact on sleep quality.

ABSTRACT:

Introduction

Spike-wave discharges (SWDs) are pathological brain oscillations caused by abnormal thalamocortical synchronization and are a hallmark of several epileptic syndromes. While several experimental models are characterized by SWDs during wakefulness and mimic several key features of absence epilepsy, the spontaneous occurrence of SWDs during sleep has been reported in a limited number of studies. Here, we report a comprehensive characterization of the electrophysiological profile and sleep-wake cycle of a mouse strain previously shown to present sleep-associated SWDs.

Methods

Inbred AJ mice from Jackson Laboratory (JAX) and matched control mice were instrumented for chronic video-EEG/EMG recordings. Data obtained during two 24-hour recording sessions were analyzed t

SUBMITTER: Del Gallo F 

PROVIDER: S-EPMC12855067 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature