Functional alteration of divided attention in people living with HIV based on a task-fMRI study.

ABSTRACT:

Background

Impaired attention is a key feature of HIV-associated brain damage, and people living with HIV (PLWH) often have potential visual-auditory perceptual deficits. This study aimed to explore functional alterations in divided attention in PLWH using a parallel audio-visual spatiotemporal task with multimodal functional magnetic resonance imaging (fMRI) and to explore candidate neuroimaging markers of HIV-related attention impairment.

Methods

Thirty-one cognitively unimpaired PLWH and 34 healthy controls (HC) completed a divided attention task during fMRI via a modified Posner paradigm. Behavioral performance and task-related brain activation were compared between the two groups. Seed-based whole-brain functional connectivity (FC) maps were computed in resting-state fM

SUBMITTER: Chen J 

PROVIDER: S-EPMC12855078 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature