Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development.

ABSTRACT: Flavin and deazaflavin biosynthesis are highly conserved pathways in mycobacteria, including in Mycobacterium tuberculosis (M.tb). Flavin biosynthesis on one hand is required to produce FMN and FAD, two essential cofactors required to support the flavin intensive lifestyle of mycobacteria. Deazaflavin biosynthesis on the other hand provides F420, an important cofactor used by mycobacteria to curtail antimicrobial and immunological stressors. Given these crucial roles for mycobacterial survival and virulence, these connected pathways have been a recent focus of drug discovery efforts. In addition to providing these important cofactors, studies have shown that the intermediates of this pathway are required to produce metabolic antigens presented by the MHC class I related prote

SUBMITTER: Oketade N 

PROVIDER: S-EPMC12855090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature