Association of serum 25-hydroxyvitamin D and homocysteine "double-risk" status with executive dysfunction in older adults with hypertension.

ABSTRACT:

Background

Executive dysfunction is common in adults with hypertension and undermines self-management. Low 25-hydroxyvitamin D [25(OH)D] and elevated homocysteine may damage the endothelium and white matter, while their non-linear dose-response and joint effects on executive dysfunction are unclear.

Methods

We conducted a single-center, prospective, cross-sectional study of inpatients aged ≥60 years with hypertension (November 2023-July 2024). Exposures were vitamin D deficiency [25(OH)D < 20 ng/mL] and hyperhomocysteinemia (hymocysteine ≥15 μmol/L), combined into a four-level dual-risk variable. Executive function was a composite of four tests. Non-linear associations were estimated with logistic regression using restricted cubic splines. Multiplicative interaction was asse

SUBMITTER: Tan L 

PROVIDER: S-EPMC12855134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature