Insulin-like growth factor 1 (IGF-1)-induced changes in cardiac inducible nitric oxide synthase (iNOS) in obese rats.

ABSTRACT:

Introduction

The role of insulin-like growth factor 1 (IGF-1) in preserving cardiovascular (CV) health, a well-established fact, cannot be overstated. IGF-1 affects inducible nitric oxide synthase (iNOS) activity, contributing to metabolic homeostasis by promoting insulin and glucose metabolism. Excessive iNOS production is involved in the occurrence and progression of insulin resistance and CV diseases (CVD). This study aimed to assess the in vivo impact of IGF-1 on the activity and gene expression of iNOS in the hearts of obese rats, through the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway.

Methods

Male adult Wistar rats were fed a standard (Control) or a high-fat (HF) diet for 12 weeks. After the 12^th week, half of the Control and

SUBMITTER: Zafirovic S 

PROVIDER: S-EPMC12855136 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature