Sex-specific associations between systemic autoantibodies and allergic sensitization or allergic disease - results from a population-based study.

ABSTRACT:

Objective

So far, knowledge of determinants of the presence of systemic autoantibodies (AABs) in the population is limited. Here, we investigated possible associations between serum AABs and allergies, using data on allergic sensitization and diagnoses of allergic diseases.

Methods

In 331 participants of a population-based study, 5 humoral systemic AABs and 7 AAB screening tests were analyzed. Allergic sensitization was characterized by specific IgE concentrations in serum samples (CAP class ≥ 2); additionally, self-reported diagnoses of allergic diseases were used as exposure variables. Multivariable adjusted logistic regression models were applied to explore the association with AAB test positivity; all analyses were stratified by sex. In a sensitivity analysis, AAB test r

SUBMITTER: Linseisen J 

PROVIDER: S-EPMC12855144 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature