Uncovering pleiotropic loci linking keratoconus and allergic diseases through integrative genomic analyses.

ABSTRACT: Keratoconus (KC) is a progressive corneal disease increasingly linked to immune dysregulation. Epidemiological studies have suggested comorbidity between KC and allergic diseases such as atopic dermatitis (AD), allergic conjunctivitis (AC), allergic rhinitis (AR), and allergic asthma (AA), yet their shared genetic mechanisms remain unclear. To investigate the shared genetic architecture between KC and four common allergic conditions, we integrated genome-wide association study (GWAS) summary statistics using a multi-omics framework. We applied linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL) to assess genome-wide genetic correlations. Pleiotropic variants were identified using the PLACO method and functionally annotated with FUMA. Bayesian colocalization

SUBMITTER: Li G 

PROVIDER: S-EPMC12855181 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature