In vitro evaluation of the anthelmintic activity of citrus flavonoids against free-living and parasitic nematodes.

ABSTRACT: Helminth infections remain a significant global health and economic burden, and the growing emergence of resistance to frontline anthelmintic drugs such as albendazole and ivermectin underscores the urgent need for novel therapeutic strategies. Flavonoids, a diverse group of plant-derived polyphenolic compounds, have gained attention for their broad-spectrum biological activities, including potential antiparasitic properties. This study aimed to investigate the anthelmintic potential of orange-derived flavonoids using two complementary models: the free-living nematode Caenorhabditis elegans (wild-type, albendazole-resistant, and ivermectin-resistant strains) and the muscle-stage larvae of Trichinella spiralis as a representative parasitic nematode. Among the five flavonoids tested, quercet

SUBMITTER: Srisuksai K 

PROVIDER: S-EPMC12855199 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature