Biological and prognostic relevance of A-to-I RNA editing across consensus molecular subtypes of colon cancer.

ABSTRACT: Colorectal cancer (CRC) is the second most frequently diagnosed cancer worldwide and represents a major challenge for public health. Despite advances in molecular profiling, important gaps remain in our understanding of tumorigenesis and the regulatory mechanisms underlying CRC progression. The most widely adopted classification system is the Consensus Molecular Subtypes (CMS), which stratifies CRC into four biologically distinct subtypes. We investigated the role of A-to-I RNA editing across CMS subtypes in a cohort of 100 CRC patients at various disease stages. Bulk RNA-seq data were analyzed using REDItools to detect editing events, focusing on both recoding sites and edits within repetitive elements, such as Alu sequences. Furthermore, expression levels of the ADAR enzyme family were a

SUBMITTER: Monaco D 

PROVIDER: S-EPMC12855204 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature